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Visual cortex undergoes protracted postnatal development with continuing structural and functional refinements over several months. In mature cortical circuits, transient activity-dependent synaptic plasticity modulates signal processing, information storage, and learning. It is also regulated by neuromodulators. The present study was aimed at investigating the early development of activity-dependent synaptic plasticity in vivo and in vitro using perineuronal nets (PNNs) as a marker of early developmental plasticity. Long-term depression (LTD) was induced by low-frequency stimulation (LFS) in layers II-III of the visual cortex in adult mice. PNNs were immunolabeled in ac619d1d87
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